Jean-Charles Pasquin Mariani

Functional ultrasound imaging (fUSI) is an advanced neuroimaging modality that enables non-invasive assessment of brain activity with high spatiotemporal resolution. Due to its portability and imaging capabilities, fUSI constitutes a promising alternative to functional magnetic resonance imaging (fMRI) for investigating brain connectivity, particularly in small animal models, with potential applicability to human neuroscience. In this seminar, I will present recent work from our laboratory demonstrating the utility of fUSI for mapping large-scale brain networks in the mouse. Specifically, I will discuss two studies: the first illustrates the use of fUSI to delineate widespread functional networks across the mouse brain; the second provides fUSI-based evidence implicating intrinsic fluctuations in arousal as a critical factor in the dynamic reorganization of brain network activity.

JC completed a Bachelor's degree in Mathematics and Informatics at Lycée Saint-Louis preparatory school in Paris, followed by engineering studies at ESPCI Paris, where he specialized in Physics. JC then pursued a Master’s degree in Neurotechnology at Imperial College London, focusing on electrophysiological methods, including current injection techniques for patch-clamp recordings in neurons. He began my doctoral research at the INSERM Institute of Psychiatry and Neuroscience of Paris, located at Sainte-Anne Hospital, under the supervision of Dr. Zsolt Lenkei. During his PhD. There, he developed an end-to-end platform for imaging functional connectivity in awake, behaving mice using functional ultrasound imaging (fUSI), with the goal of pharmacological fingerprinting of drugs. Since completing his PhD, he has been a postdoctoral researcher in Dr. Alessandro Gozzi’s laboratory at the Istituto Italiano di Tecnologia. His work there has contributed to the advancement of fUSI methodology, but also used fMRI data with a research focus on the emergence and modulation of large-scale brain dynamics.

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